MATERIAL and METHODS:
The study population consisted of 100 adult patients aged ≥ 18 years with isolated severe MS in sinus rhythm recruited from Cardiology Outpatient Department of our Tertiary care hospital between January 2019 and July 2020.
Patients with any of the following were excluded from the study:
  1. Concomitant mitral regurgitation (more than mild)
  2. Concomitant aortic stenosis and/or regurgitation (more than mild)
  3. History of mitral commisurotomy or valvuloplasty
  4. Associated congenital heart disease
  5. Left ventricular systolic dysfunction (ejection fraction < 50%)
  6. Associated diabetes mellitus, hypertension, chronic kidney disease or coronary artery disease.
  7. Associated pregnancy
  8. Currently on oral anticoagulants or antiplatelet drugs
  9. Poor ECHO window The study was approved by the institutional ethical committee and written informed consent was taken from all the subjects. An initial screening transthoracic echocardiography (TTE) was done and patients meeting our inclusion/ exclusion criteria were given an appointment for undergoing both TTE and TEE.